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Lamda phage

Lambda phage is a bacteriophage that infects E. coli bacteria. It has two life cycles: a lytic cycle and a lysogenic cycle. In the lytic cycle, the phage genome is transferred into the bacterial cell where it replicates and causes the bacterial cell to burst, releasing new phage particles. In the lysogenic cycle, the phage genome integrates into the bacterial chromosome and replicates with the host DNA without killing the cell. The phage can switch between these two cycles depending on environmental conditions inside the infected bacterial cell.

Technology◦Health & Medicine◦
Life cycle of  λ phage Presented by: Minhaz Ahmed BBI11014 Integrated M.Sc 3rd  semester,MBBT, Tezpur University, Assam
CONTENTS  Introduction  How genome is transferred  Lytic cycle and lysogenic cycle  Life cycle  Lytic or lysogenic?
What is lambda phage?  It is a bacterial virus, or bacteriophage , that infects the bacterial species Escherichia coli.  This virus is a temperate phage.  Temperate phages are basically bacteriophages which can choose between a lytic and lysogenic pathway of development. SOURCE:classes.midlandstech.edu
The viral DNA exists as a separate molecule within the bacterial cell.  Replicates separately from the host bacterial DNA.  Viral DNA integrates with bacterial DNA. Replicates with the host DNA
How it penetrates: It binds to the target E. coli cell, via J protein in the tail tip that interacts with the maltoporin of E. coli and injects its linear genome. TAIL FIBRE TAIL HEAD 1 DNA COLLAR BASE PLATE DNA of E. coli MALTOPORIN in E. coli 2 E. coli
LIFE CYCLE : SOURCE: Pearson Education 2004
Lytic or lysogenic? 1.lytic life cycle: occurs in cells with sufficient nutrients, protease activity is high, which breaks down cII. 2.Lysogenic life cycle: In cells with limited nutrients, protease activity is low, making cII stable.  Computer modeling and simulation suggest that random processes during infection drive the selection of lysis or lysogeny within individual cells. However, recent experiments suggest that physical differences among cells, that exist prior to infection, predetermine whether a cell will lyse or become a lysogen.
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