Comprehensive somatic mutation analysis of paired tumor-control samples using high-throughput sequencing data. This project integrates variant calling, functional annotation, and structural alteration analysis to uncover clinically relevant genomic changes, estimate tumor purity and ploidy, and explore potential therapeutic targets in oncogenomics.
shell bioinformatics r cancer somatic-variants gatk cancer-genomics igv copy-number-variation hg19 tumor-segmentation tumor-purity-estimation tpes variant-calling-and-annotation tumor-ploidy-estimation clonetv2 computational-human-genomics
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Updated
Jul 24, 2025 - Shell