oppeneaur reaction mechanism with chemdraw art

oppeneaur reaction mechanism with chemdraw art

• 1.
  OPPENEAUR REACTION Presented By: ChayanMondal ID: 181814 Chemistry Discipline Khulna University
• 2.
  Oppenauer Oxidation isthe process of conversion of secondary alcohols to ketones by selective oxidation. This reaction is named after Rupert Viktor Oppenauer. Oxidation reaction takes place in the presence of [Al(i-Pro)3] in excess of acetone. It is an aluminium alkoxide catalysed oxidation of a secondary alcohol to the corresponding ketone. This is the reverse of the Meerwein Ponndorf Verley reduction. It is a very good method to oxidise allylic alcohols to α, β- unsaturated ketones. CH3 H3C O R2 R1 OH R2 R1 O CH3 H3C OH Al(i-PrO)3 /heat INTRODUCTION
• 3.
  There are fivesteps--- 1.In the first step, alcohol coordinates with aluminium isopropoxide to form a complex 2.This complex reacts with a ketone to form a six-membered transition complex 3.The alpha-carbon of the alcohol is converted to the carbonyl carbon from the aluminium-catalysed hydride shift. 4.The acetone proceeds over a six-membered transition state. 5.The desired ketone is formed after the hydride transfer Oppenauer Oxidation Mechanism
• 4.
  Oppenauer Oxidation Mechanism