This document discusses generating and framing questions for health policy and systems research (HPSR). It outlines four key steps in HPSR: identifying the research focus and question, designing the study, ensuring quality and rigor, and applying ethical principles. The document provides guidance on starting points for HPSR questions, different types of questions, what makes a "good" HPSR question, and how to generate substantively relevant questions by speaking to stakeholders, reviewing literature, and considering different disciplinary perspectives. It also discusses moving from research purpose to question formulation and the need for more exploratory and explanatory questions that consider socio-cultural and political factors.