Carpal tunnel syndrome (CTS) arises from entrapment of the median nerve within a confined space formed by carpal bones and the transverse carpal ligament, leading to symptoms such as numbness, tingling, and pain. Causes can be acute, like trauma, or chronic due to repetitive wrist motions, with patients presenting specific signs such as nocturnal pain and weakness in grip strength. Treatment options include non-operative methods like splinting and cortisone injections, as well as surgical intervention for severe cases.