The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4
Figure 2
Sequence logos of the hNaa40p-specific substrate peptide sequences enriched from a Nα-free-peptide library.
An IceLogo of the 177 unique substrate peptides of recombinant hNaa40p is shown (255 substrate peptides in total). Numbering is such that Nt-acetylation occurs at position 0. Statistically significant residues with a p-value threshold of 0.05 or less are plotted. The amino acids heights are indicative for their degree of conservation at the indicated position. The frequency of the amino acid occurrence at each position in sequence set was compared with the human Swiss-Prot 56.0 database. Residues with statistically significant 0% frequency of occurrence as compared to Swiss-Prot are shown in pink. The N-terminal sequences of human and yeast histone H2A and H4 are indicated.